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Commercial Real Estate for Sale in Upstate SC

Commercial activity in the Upstate follows the interstates. I-85 between Greenville and Spartanburg carries the industrial and distribution demand, with BMW and its supplier network anchoring most of it; retail and office concentrate around the two downtowns and the Highway 9 and Fairview Road corridors.

Commercial runs on different diligence than residential — zoning and permitted use, environmental history, existing leases and their remaining terms, and what a building can actually be converted to. Tell us what you are trying to do and we will scope the search.

Commercial Listings

$995,000
6 Baths ⋅ 4427873 MLS
RARE RETREAT & HOSPITALITY OPPORTUNITY | 16 ACRES | SIX CABINS | SECOND BROAD RIVER | WATERFALL VIEWS An exceptional Western North Carolina retreat and recreational property where historic character, water features, accommodations and gathering spaces come together. Situated on approximately 16 acres along the Second Broad River, this distinctive property includes an approximately 4,200-SF main residence, six insulated sleeper cabins, approximately 800-SF bathhouse, 20’ x 40’ heated saltwater pool, waterfall views and extensive outdoor recreational areas. The property provides an extraordinary environment for fishing, kayaking, swimming, hiking, exploring trails, enjoying the river and gathering with family, friends or groups. The combination of Second Broad River frontage, waterfall views, trails, pool, cabins and gathering areas creates a unique recreational setting with numerous possibilities for an experienced owner/operator. Approximately $500,000 in improvements have been made since 2025, including six cabins, bathhouse, electrical, plumbing, HVAC, foundation, septic, landscaping, fencing, security gate and pool improvements. Seller reports permits and inspections associated with numerous improvements. The property currently has an established retreat operation, with approximately 15 beds/10 rooms, six cabins and infrastructure designed to accommodate guests and gatherings. An established business entity and related operation may be available for transfer, subject to mutually acceptable terms. With its historic residence, Second Broad River setting, waterfall views, recreational amenities, extensive improvements and proximity to Forest City and regional Western North Carolina markets, this is a highly unusual opportunity for an experienced investor or operator. SEE AGENT REMARKS REGARDING THE RECORDED DEED RESTRICTION, INTENDED USE, TITLE, FINANCING AND BUYER DUE DILIGENCE.

252 Spencer Street, Ellenboro

$660,000
1 Baths ⋅ 1604670 MLS
YOUR BUSINESS DESERVES A LOCATION LIKE THIS. Give your business a professional presence in an outstanding Greenville location with the visibility, convenience, and character that are increasingly hard to find. Set along high-traffic W Stone Avenue, this 1,380-square-foot commercial office combines a polished business setting with the inviting character of a Southern bungalow, complete with shaker siding and a covered front porch. Inside, you'll find a welcoming reception area and five offices, with one offering the flexibility to serve as an over size conference room. A dedicated break-room features a kitchenette with counters, cabinets, and sink, along with space for a refrigerator, and a washer and dryer hookup. The layout is well suited to a professional practice while providing room to make the space work for your business. Outside, 10 dedicated parking spaces provide an exceptional advantage for a five-office professional setting—plenty of room for your team and clients without the parking challenges often associated with a downtown-adjacent location. Existing signage adds visibility along W Stone Avenue, while downtown Greenville, Greenlink transit, and the downtown trolley are all conveniently nearby. Zoned Commercial/Office and currently configured for professional office use, this is an opportunity to own a distinctive business address in one of Greenville's most desirable locations. If your business has reached the point where location, visibility, parking, and professional presence matter, take a closer look at 308 W Stone Avenue.

308 W Stone Avenue, Greenville

$399,000
2 Baths ⋅ 4427673 MLS
Location, Location, Location! Welcome to this one-of-a-kind office and residential property, originally constructed in 1938 and thoughtfully updated to combine timeless character with modern convenience. This unique home offers comfortable living space along with a versatile flex area currently outfitted as a fully equipped hair salon—an ideal opportunity for an entrepreneur, home-based professional, or anyone looking for a property with exceptional flexibility. Step inside to discover an inviting living room featuring a charming vintage fireplace and an adjoining sunroom, creating the perfect retreat for reading, meditation, or simply relaxing. The oversized eat-in kitchen is beautifully designed and offers abundant prep space, quartz countertops, a spacious island with seating, and plenty of room for a dining table and chairs. Kitchen appliances are included. The spacious primary bedroom easily accommodates a king-size bed and offers convenient access to the primary bathroom, complete with an oversized walk-in shower and generous vanity. Just off the primary bathroom is a combination walk-in closet and laundry room, with a stackable washer and dryer included. The home also features a second bedroom and hall bathroom. The true hidden gem is the third bedroom, currently designed as a professional hair salon/barber shop. The space includes a styling station, hair dryers, shampoo bowl, and storage closet. Whether you continue using it as a salon, transform it into a private office, or return it to a traditional third bedroom, the possibilities are yours. A stylish sliding barn door provides separation from the living room while adding a modern design accent. Original hardwood floors throughout the home top off the charm and uniqueness of the dwelling. Furniture currently in the home at the time of showing may be included in the purchase price unless otherwise tagged. Specific inclusions will be outlined and agreed upon in an acceptable offer to purchase. This truly unique property is ready for its next chapter. Whether you're looking for a distinctive residence, a flexible live/work opportunity, or space to bring your entrepreneurial vision to life, this Kannapolis gem offers character, versatility, and a prime location.

1670 Dale Earnhardt Boulevard, Kannapolis

$1,599,000
1604370 MLS
INVESTMENT OPPORTUNITY – 15-UNIT RESIDENTIAL RENTAL PORTFOLIO – MOTIVATED SELLER! Don’t miss this opportunity to acquire a diversified, income-producing residential portfolio consisting of 15 rental units located throughout Anderson, Pendleton, Piedmont and Liberty, SC. The portfolio includes a mix of site-built single-family homes (5) and manufactured homes (10), with multiple properties offering additional land. 12 of the 15 units are currently tenant occupied, with the remaining 3 actively being marketed for rent, providing an opportunity for additional immediate income as they are leased. The portfolio offers an established rental history with current rents that provide potential for future increases and additional income growth. Properties are being offered together as a portfolio and are sold AS-IS. This is an excellent opportunity for an investor looking to acquire multiple income-producing properties across strong Upstate South Carolina rental markets in a single transaction. PLEASE BE RESPECTFUL OF CURRENT TENANTS. DO NOT DISTURB TENANTS OR ENTER ANY PROPERTY WITHOUT A CONFIRMED APPOINTMENT. You can do a drive-by, but do not walk around the properties. The photos have been photoshopped to remove some of the tenants personal belongings. Rent roll and additional property information in documents. Buyer/Buyer’s Agent to verify all information deemed important, including property details, acreage, rental information, leases, title status, zoning and intended use. Square footage, acres, taxes all added together.

215 W Roosevelt Drive, Anderson

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“ Based on information submitted to the MLS GRID as of . All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Some IDX listings have been excluded from this website. Properties may or may not be listed by the office/agent presenting the information © 2026 Canopy MLS as distributed by MLS GRID”

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